Copper Chelation

Copper is a trace element tightly regulated within our bodies. One of copper’s functions is to promote angiogenesis (formation of new blood vessels), meaning it can also promote malignant angiogenesis, enabling tumor growth, invasion and metastasis.

Also known by these names

  • Copper depletion

Key Points

  • Copper promotes angiogenesis (formation of new blood vessels in our bodies.
  • Researchers are finding that copper chelation promotes tumor dormancy and helps prevent relapse, especially among women with triple-negative breast cancer.
  • Chelating drugs require a prescription and carry a risk of side effects.

Treating the Cancer

Working against cancer growth or spread, improving survival, or working with other treatments or therapies to improve their anticancer action

Over the years, researchers have studied how and whether removing copper from the body through a process called “chelation” affects tumor angiogenesis. Using the copper-chelating drug tetrathiomolybdate (TM) in both laboratory studies and in people with advanced cancer, researchers are finding that copper chelation promotes tumor dormancy and helps prevent relapse, especially among women with triple-negative breast cancer (TNBC).1

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Clinical Evidence

Breast Cancer

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Colorectal Cancer

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Kidney Cancer

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Prostate Cancer

 

  • Slower PSA progression was seen in a small clinical trial of TM, but with uncertain clinical significance.8
  • Copper depletion with TM did not delay disease progression in a small clinical trial of patients with asymptomatic metastatic hormone-refractory prostate cancer.9

 

Unspecified Metastatic Cancer

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Cautions

Chelating drugs require a prescription, carry a risk of side effects and should be taken only as directed by a qualified healthcare professional who will monitor their use.

Chelation with TM may promote breast cancer stem cells, potentially leading to recurrence.13

Integrative Programs, Protocols and Medical Systems

For more information about programs and protocols, see our Integrative Programs and Protocols page.
  • Programs and protocols
    • Block program: off-label use for cancer to inhibit angiogenesis15
    • McKee guidelines on copper chelation.16
    • McKinney protocols17
      • Ovarian cancer
      • Melanoma

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More Information

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