Modified Citrus Pectin

Also known by these names

  • MCP
  • Modified Citrus Pectin Power (brand name)
  • Pectin
  • Pectinic Acid

Key Points

  • Modified citrus pectin (MCP) is an altered form of natural pectin, a soluble plant fiber.
  • Citrus pectin in food doesn’t seem to have the same effects as modified citrus pectin.
  • Modified citrus pectin is of interest to BCCT because of its anticancer potential, especially anti-metastatic activity, in laboratory and animal studies. Human studies are needed to verify these results.
  • MCP may lower PSA in prostate cancer.
  • MCP is used to treat diarrhea and lower cholesterol.
  • Pectin is “generally recognized as safe” in the US.
  • A few minor side effects as well as interactions with some drugs and supplements are noted. Caution and medical supervision are advised.

Pectin is a soluble plants fiber found in highest concentrations in apples and the peel and pulp of citrus fruits. Modified citrus pectin (MCP) is an altered form of citrus peel pectin that is reportedly more absorbable in the body. As a result, natural citrus pectin may not have the same effects on cancer as modified citrus pectin.1

Treating the Cancer

Working against cancer growth or spread, improving survival, or working with other treatments or therapies to improve their anticancer action

In lab, animal and preliminary human studies, MCP has shown anticancer effects in these cancers:

  • Breast cancer
  • Colon cancer
  • Lung cancer
  • Melanoma
  • Prostate cancer

Clinical Evidence

MCP significantly increased prostate specific antigen doubling time in patients with recurrent prostate cancer in a small study.2

Lab and Animal Evidence

Read more

Cautions

Modified citrus pectin is “generally regarded as safe” in the US. However, MCP can cause mild side effects as well as some potentially serious interactions with drugs and supplements, including digoxin, lovastatin and tetracycline. MCP may also slow or reduce absorption of some oral drugs.14  Consult with your pharmacist for interactions, and discuss using MCP with your doctor.

Access

Pectin is found in common food sources, and modified citrus pectin is widely available in supplement form.

Non-cancer Uses of Modified Citrus Pectin

BCCT has not reviewed the effectiveness of this therapy for non-cancer uses.

  • Treating diarrhea
  • Treating high cholesterol
  • Chelating heavy metals

Dosing

Although clinical trials have not established an optimal modified citrus pectin dose during or post cancer treatment, suggested dosages are listed in the integrative cancer care protocols, plans and references below. Levels of active ingredients of natural products can vary widely between and even within products. See Quality and Sources of Herbs, Supplements and Other Natural Products.

More information about dosing pectin is available from these sources:

Integrative Programs, Protocols and Medical Systems

For more information about programs and protocols, see our Integrative Programs and Protocols page.
  • Programs and protocols
    • Alschuler & Gazella complementary approaches15
      • Melanoma
      • Prostate cancer
    • Block program16
      • Tips for diarrhea
      • Reduce platelet aggregation (reducing risk for clots)
    • Chang strategies17
    • McKinney protocols18
      • General cancer
      • Breast cancer
      • Head and neck cancer
      • Lung cancer
      • Myelodysplastic syndrome
      • Ovarian cancer
      • Pancreatic cancer
      • Prostate cancer
      • Sarcoma
      • Skin cancer

Written by Laura Pole, RN, MSN, OCNS, and reviewed by Nancy Hepp, MS; most recent update April 17, 2019. Note: BCCT has not conducted an independent review of research of modified citrus pectin. This summary draws primarily from Memorial Sloan Kettering Cancer Center About Herbs and Anticancer Fund website.

View All References

More Information

Enter your comments or questions below.

Comments (0)




Allowed tags: <b><i><br>Add a new comment: