Vitamin E

Also known by these names

  • Tocopherol (alpha, beta, gamma and delta)
  • Tocotrienol (alpha, beta, delta and gamma)
  • RRR-alpha-tocopherol (synthetic)

Vitamin E is a natural antioxidant found in the following foods:

  • Eggs
  • Nuts
  • Green leafy vegetables
  • Wheat germ
  • Whole grains
  • Plant oils, especially from rice bran, sunflower, safflower, cottonseed and palm

Key Points

  • Vitamin E is a generic term for multiple natural and synthetic compounds, all of which are antioxidants.
  • BCCT is interested in vitamin E because some forms may have anticancer properties.
  • Vitamin E may reduce side effects of some conventional cancer therapies.
  • Vitamin E is included in a number of integrative care cancer protocols.
  • No published clinical trials to date describe using vitamin E alone as an anticancer therapy.
  • Vitamin E has low toxicity and is usually well tolerated in low doses.
  • Vitamin E can cause side effects as well as react with some prescription drugs. Vitamin E is contraindicated in some medical conditions. Caution and medical supervision are advised.

Vitamin E is also available in supplement form.

Read more

Treating the Cancer

Working against cancer growth or spread, improving survival, or working with other treatments or therapies to improve their anticancer action

No reported clinical trials have used vitamin E as a stand-alone  anticancer treatment. Most of the studies in humans look at its use in combination with drugs or in combination with conventional chemotherapy or radiotherapy.

Lab and Animal Evidence

In lab and animal studies, vitamin E has reportedly inhibited protein kinase C activity, which affects cell proliferation (growth) and differentiation. Studies of the tocotrienol forms of vitamin E suggest they may be effective against a number of cancers, including breast, pancreatic, prostate and skin cancer.3

Read more

Managing Side Effects and Promoting Wellness

Managing or relieving side effects or symptoms, reducing treatment toxicity, supporting quality of life or promoting general well-being

Clinical Evidence

Use in combination with drugs or in combination with conventional chemotherapy or radiotherapy shows that vitamin E may reduce side effects such as oral mucositis7 and peripheral neuropathy.8

Reducing Risk

Reducing the risk of developing cancer or the risk of recurrence

Results published in 2014 of a large-scale randomized trial in men showed vitamin E and C supplementation had no immediate or long-term effects on the risk of total cancers, prostate cancer, or other site-specific cancers.9

Cautions

Low doses of vitamin E are considered relatively nontoxic. However, vitamin E can cause side effects and drug interactions, some of which can be serious. Daily levels at or above 400 IU are not recommended.

A meta-analysis of 19 clinical trials combining results of 135,967 participants found that daily supplementation of more than 400 IU is associated with an increase in all-cause mortality. Higher levels of supplements were associated with greater mortality.10

Consult with your pharmacist for interactions, and discuss using vitamin E with your doctor. See the following sources for more information on specific side effects, cautions and contraindications:

Access

Vitamin E is widely available in food sources and in supplements.

Dosing

BCCT does not recommend therapies or doses, but only provides information for patients and providers to consider as part of a complete treatment plan. Patients should discuss therapies with their physicians, as contraindications, interactions and side effects must be evaluated.

As noted above, levels of active ingredients of natural products can vary widely between and even within products. See Quality and Sources of Herbs, Supplements and Other Natural Products.

Although no optimal vitamin E dose during or after cancer treatment has been established, suggested dosages are listed in these sources:

Integrative Plans, Protocols and Medical Systems

For more information about plans and protocols, see our Integrative Plans and Protocols page.

Integrative oncology clinicians such as Keith Block, Dwight McKee and Lise Alschuler incorporate vitamin E supplementation into care either during active cancer treatment or after treatment care (or both) to prevent recurrence or secondary cancers.

  • Plans, protocols and programs
    • Alschuler & Gazella complementary approaches11
      • Breast cancer
      • Cervical cancer
      • Colon cancer
      • Esophageal cancer
      • Gastric cancer
      • Head and neck cancer
      • Kidney cancer
      • Ovarian cancer
      • Thyroid cancer protocol
      • Guidance for support during conventional treatment and for treatment recovery
    • Bastyr University Integrative Oncology Research Center protocol for stage IV breast cancer12
    • Block program13
      • Chemopreventive nutraceutical in remission maintenance program:
        • Brain cancer
        • Breast cancer
        • Colon cancer
        • Leukemia case
        • Prostate cancer
      • Core diet plan
      • Combination antioxidant support formula and terrain modification
      • Anti-inflammatory support
      • Immune surveillance booster
      • Circulatory support supplement
      • Remission maintenance program
    • Lemole, Mehta & McKee protocols14
      • Bladder cancer
      • Breast cancer
      • Lung cancer
      • Prostate cancer
    • McKinney protocols15
      • General cancer
      • Bladder cancer
      • Brain/nerve cancer
      • Breast cancer
      • Carcinoid/neuroendocrine cancer
      • Cervical cancer
      • Colorectal cancer
      • Esophageal cancer
      • Head and neck cancer
      • Kidney cancer
      • Leukemia
      • Lymphoma
      • Multiple myeloma
      • Myelodysplastic syndrome
      • Prostate cancer
      • Skin cancer
      • Stomach cancer
      • Thyroid cancer
      • Uterine cancer

Commentary

According to Raymond Chang, MD, tocotrienols are much more potent than the tocopherol form of E vitamins, especially against cancer (especially gamma tocotrienol).16

Keith Block, MD: “Avoid high doses of single antioxidant supplements . . . Labile antioxidants--which include vitamins A, C and E, selenium and beta-carotene--can change into pro-oxidants . . . Thus they can increase the oxidative stress of your terrain and, if used without proper supervision, enhance the growth and spread of cancer cells. Used in the right dosages and combinations, however, they can help control malignancy.”17 Dr. Block advises using antioxidants like vitamin E in a mix of diverse antioxidants to promote a synergistic effect.18

Non-cancer Uses of Vitamin E

BCCT has not reviewed the effectiveness of this therapy for non-cancer uses.

  • Preventing progression of Alzheimer’s disease
  • Treating arthritis
  • Preventing cardiovascular complications of diabetes
  • Treating fatty liver diseases
  • Reducing hot flashes

Written by Laura Pole, RN, MSN, OCNS, and reviewed by Nancy Hepp, MS; most recent update January 15, 2019. Note: BCCT has not conducted an independent review of research of vitamin E. This summary draws primarily from CAM-Cancer’s Summaries and the Memorial Sloan Kettering Cancer Center’s About Herbs.

View All References

More Information

Enter your comments or questions below.

Comments (0)




Allowed tags: <b><i><br>Add a new comment: