Pomi-T

Key Points

  • Pomi-T is a food supplement capsule containing green tea, pomegranate seed extract, broccoli extract and turmeric.
  • Pomi-T interests BCCT because of the impressive results of a trial evaluating its use in men with prostate cancer undergoing active surveillance or watchful waiting.
  • It is listed and described in the NCI’s PDQ Prostate Cancer, Nutrition, and Dietary Supplements as one of the multicomponent complementary therapies used in preventing and treating prostate cancers.
  • Although initial research is promising, no clinical evidence yet shows that Pomi-T has any impact on cancer outcomes.
  • Pomi-T in clinical trial was well tolerated, although some people may be hypersensitive to one or more components in Pomi-T. Some of the components can potentially interact with prescription drugs. Consult with your pharmacist for interactions, and discuss using Pomi-T with your doctor.

Pomi-T® is a food supplement capsule containing green tea, pomegranate seed extract, broccoli extract and turmeric. The individual components in Pomi-T are each rich in polyphenols, natural plant-based phytochemicals that are associated with lowering risk for a number of chronic illnesses and are known for anticancer effects. 

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Treating the Cancer

Working against cancer growth or spread, improving survival, or working with other treatments or therapies to improve their anticancer action

Clinical Evidence

Pomi-T was tested in a double-blind, placebo-controlled, randomized trial involving 199 men with early-stage prostate cancer in active surveillance or watchful waiting. After six months of treatment, the placebo group's prostate-specific antigen (PSA) levels rose by 78.5 percent, while the Pomi-T treatment group's PSA rose by 14.7 percent. Rising PSA levels are a marker of potential cancer activity.1 The researchers concluded that there was a significant short-term favorable effect on PSA in the men taking Pomi-T.2

Components of Pomi-T

The individual ingredients in Pomi-T are all considered to be rich in polyphenols, natural plant-based phytochemicals that are associated with lowering risk for a number of chronic illnesses as well as having anticancer effects, as described in the study of Pomi-T:3

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Although one small clinical studies snowed significant effects of Pomi-T on PSA levels, it was of short duration (six months), and no impact on cancer incidence, quality of life or mortality was established.4 Pomi-T shows promise, but as yet no clinical evidence of impact on cancer is available..5

Lab and Animal Evidence

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Access

Pomi-T is a food supplement and doesn’t require a prescription. It is generally available at retail pharmacies, supplement stores and online.

Cautions

Because Pomi-T doesn’t contain the sugar in pomegranate juice, use is generally appropriate for patients with diabetes.

Safety of Pomi-T in pregnancy hasn’t been established. However, no evidence shows that turmeric, broccoli, pomegranate or green tea adversely affect pregnancy.

Side Effects/Adverse Events

Pomi-T was well tolerated in the study, although those taking the supplement tended to have a few side effects compared to those in a placebo group:

  • More flatulence and loose bowels
  • Mild indigestion, which disappeared if Pomi-T was taken with food

Drug Interactions

Pomegranate has the potential to interact with some drugs, such as warfarin, anti-hypertensives or anti-convulsants. For more information on potential drug interactions see Pomi-T website FAQ’s: Does Pomi-T interact with other drugs?  

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Dosing

BCCT does not recommend therapies or doses, but only provides information for patients and providers to consider as part of a complete treatment plan. Patients should discuss therapies with their physicians, as contraindications, interactions and side effects must be evaluated. Levels of active ingredients of natural products can vary widely between and even within products. See Quality and Sources of Herbs, Supplements and Other Natural Products.

The Pomi-T official website contains a number of tips on dosing as well as improving the absorption and bioavailability of Pomi-T. The UK site also describes an i-Phone app created to help patients calculate their PSA doubling time between two time points. See the Pomi-T FAQ’s page (Q. How can I accurately follow my PSA doubling time?).

Integrative Programs, Protocols and Medical Systems

For more information about programs and protocols, see our Integrative Programs and Protocols page.

Pomi-T is not yet listed in any of the protocols or systems that BCCT references, although several of its constituent ingredients are used in protocols.

Commentary

From BCCT staff, January 4, 2018: In a 2013 post, integrative oncologist Dr. Brian Lawenda cautions, “POMI-T is NOT A TREATMENT FOR PROSTATE CANCER. Make sure you have first discussed this with your cancer care team before taking POMI-T as the individual ingredients have the potential to interact with other therapies you may be receiving.”6 Thus, although Pomi-T has been shown to reduce PSA in early stage prostate cancer, no evidence to date indicates it could stand alone as a treatment for prostate cancer.

Non-cancer Uses of Pomi-T

Because all four Pomi-T ingredients have anti-inflammatory properties, a trial is planned to evaluate the effect of Pomi-T on arthritis.7  

BCCT has not reviewed the effectiveness of this therapy for non-cancer uses.

Written by Laura Pole, RN, MSN, OCNS, and Nancy Hepp, MS; most recent update on April 1, 2019. Note: BCCT has not conducted an independent review of research of Pomi-T. We have drawn from the following sources to create this summary:

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